誤診原因及與急性心肌梗死的鑒別:3例患者都有心肌缺血的癥狀、ST段抬高或Q波等ECG改變,并且心肌標記物也是升高的,極易誤診為急性心肌梗死。近幾年來隨著對本病的認識,統(tǒng)計發(fā)現(xiàn)該病約占以急性心肌梗死收住院的2%。但前者多見于有應(yīng)激史的老年女性,心肌標記物僅輕到中度升高峰值多在24 h內(nèi),并且與室壁運動異常的程度及ECG提示的病變范圍不符合。冠狀動脈造影示梗死相關(guān)冠脈血流通暢有助于早期確診。除此之外ECG亦有差異,前者ST段的抬高是暫時性的,胸前導(dǎo)聯(lián)的ST段抬高的幅度要低于前壁心梗且較少出現(xiàn)對應(yīng)導(dǎo)聯(lián)ST 段壓低[11],且V4~V6 導(dǎo)聯(lián)ST 段抬高幅度大于V1~V3 導(dǎo)聯(lián),但單純ECG差異尚不能作為確診條件?傊瑧(yīng)激性心肌病極易誤診為急性心肌梗死,二者治療截然不同,作為接診的臨床醫(yī)師應(yīng)該提高警惕。尤其是有明顯應(yīng)激因素的老年女性,出現(xiàn)胸前導(dǎo)聯(lián)ST段抬高、心肌缺血癥狀,不要急于診斷,如果心肌標志物輕到中度升高與ECG提示的病變范圍不符時,要及時行床旁超聲心動及冠狀動脈造影除外此病。
【參考文獻】
1 Bybee KA,Kara T,Prasad A,et al.Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction.Ann Intern Med,2004,41:858-865.
2 Gianni M,Dentali F,Grandi AM,et al.Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review.Eur Heart J,2006,27:1523-1529.
3 Elesber A,Prasad A,Lennon R,et al.Four-year recurrence rate and prognosis of the apical ballooning syndrome.J Am Coll Cardiol,2007,10:448-452.
4 Primetshofer D,Agladze R,Kratzer H,et al.Tako-Tsubo syndrome: an important differential diagnosis in patients with acute chest pain.Wien Klin Wochenschr,2010,22:37-44.
5 Nef HM,Mollmann H,Akashi YJ,et al.Mechanisms of stress (Takotsubo) cardiomyopathy.Nat Rev Cardiol,2010,12:187-193.
6 Wittstein IS,Thiemann DR,Lima JA,et al.Neurohumoral features of myocardial stunning due to sudden emotional stress.N Engl J Med,2005,352:539-548.
7 APaham J,Mudd JO,Kapur NK,et al.Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists.J Am Coll Cardiol,2009,53:1320-1325.
8 Prasad A.Apical ballooning syndrome: an important differential diagnosis of acute myocardial infarction.Circulation,2007,115:56-59.
9 Prasad A,Lerman A,Rihal CS.Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction.Am Heart J,2008,155:408-417.
10 Kimura K,Tanabe-Hayashi Y,Noma S,et al.Images in cardiovascular medicine.Rapid formation of left ventricular giant thrombus with Takotsubo cardiomyopathy.Circulation,2007,115:620-621.
11 Bybee KA,Motiei A,Syed IS,et al.Electrocardiography cannot reliably differentiate transient left ventricular apical ballooning syndrome from anterior ST-segment elevation myocardial infarction.J Electrocardiol,2007,40:381-386