基質金屬蛋白酶_7及其組織抑制因子_1在胃癌中的表達與浸潤、轉移的關系研究

基質金屬蛋白酶_7及其組織抑制因子_1在胃癌中的表達與浸潤、轉移的關系研究

【摘要】 目的：探討基質金屬蛋白酶_7(MMP_7及其組織抑制因子_1(TIMP_1在胃癌中的表達與浸潤、轉移的關系。方法：應用免疫組化檢測36例胃癌標本中腫瘤組織及癌旁組織中MMP_7和TIMP_1的表達，并進行回顧性隨訪。結果：胃癌組織中MMP_7陽性表達率(58.3%明顯高于癌旁組織(5.6%，P<0.01，胃癌組織中TIMP_1陽性表達率(44.4%與癌旁組織(50.0%無統(tǒng)計學意義。胃癌中MMP_7和TIMP_1之間表達強度關系無明顯相關性。TIMP_1表達隨胃癌TNM分期增加而減少(P<0.05。結論：MMP_7表達與胃癌組織學行為有關，TIMP_1可能抑制胃癌的浸潤、轉移。

【關鍵詞】 胃癌;基質金屬蛋白酶_7;基質金屬蛋白酶抑制因子_1

Expression of Matrix Metalloproteinase_7 and Tissue Inhibitor of Metalloproteinase_1

in Gastric Carcinoma: Exploration Mechanism of Invasion and MetastasisSUN Shu_ming，LU Xiao_feng，WU Li�餰，LIN Xiao_hong，LIN Hao_yu

(Department of General Surgery，The First Affiliated Hospital，Shantou University Medical College，Shantou 515041，China[Abstract]Objective：To investigate the expression of matrix metalloproteinase_7(MMP_7and tissue inhibitor of metalloproteinase_1(TIMP_1in gastric carcinoma and their relationship with tumor cell invasion and metastasis. Methods：The immunohistochemistry was used to detect the expression of MMP_7 and TIMP_1 in 36 patients with gastric carcinoma. Results: The positive expression rate of MMP_7(58.3%in gastric carcinoma was higher than that of paracarcinoma mucosa(5.6%(P<0.05，there was no difference of the expression of TIMP_1 between gastric cancer(44.4%and paracarcinoma mucosa(50.0%. The expression of TIMP_1 decreased with the increase of TNM staging(P<0.05. Conclusion: The expression of MMP_7 is related to the behavior of gastric carcinoma，and the expression of TIMP_1 probably inhibits tumor cell metastasis醫(yī).學全.在.線網(wǎng)站m.payment-defi.com.

[Key Words]gastric carcinoma，matrix metalloproteinase_7，tissue inhibitor of metalloproteinase_1

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