醫(yī)學(xué)免費(fèi)論文:肺炎支原體肺炎患兒血清細(xì)胞因子與免疫球蛋白的檢測(cè)及其臨床意義

醫(yī)學(xué)免費(fèi)論文:肺炎支原體肺炎患兒血清細(xì)胞因子與免疫球蛋白的檢測(cè)及其臨床意義

【摘要】 目的 探討檢測(cè)肺炎支原體肺炎(MPP)患兒血清細(xì)胞因子(IL��6、IL��8、TNF�拨�)、免疫球蛋白(IgA、IgM、IgG)及補(bǔ)體(C3、C4)的臨床意義。方法 60例MPP患兒(觀察組)和60例健康兒童(正常對(duì)照組)為研究對(duì)象，采用放射免疫分析法測(cè)定IL��6、IL��12、TNF�拨�，采用速率散射比濁法測(cè)定血清免疫球蛋白(Ig)和補(bǔ)體(C)。結(jié)果 觀察組血清IL��6、IL��8的水平與正常對(duì)照組比較上升(P<0.05);而TNF�拨了�平2組比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05);觀察組血清免疫球蛋白IgA、IgM、IgG水平、補(bǔ)體C水平與正常對(duì)照組比較上升(P<0.05)。結(jié)論 血清IL��6、IL��8、免疫球蛋白IgA、IgM、IgG，補(bǔ)體C3、4在MPP中起著重要作用，檢測(cè)這些指標(biāo)可以較準(zhǔn)確地判定MMP患兒病情和預(yù)后，值得臨床推廣應(yīng)用。

【關(guān)鍵詞】 肺炎支原體肺炎;白介素��6;白介素��8;腫瘤壞死因子;免疫球蛋白Ig;補(bǔ)體C

Clinical significance of serum cytokines and immunoglobulin levels in children with mycoplasma pneumoniae pneumonia XIE Zhicai, LV Hui, ZHOU Shuming. Longgang Central Hospital, Guangdong, Shenzheng 518116,China

【Abstract】 Objective To investigate the clinical significance of detecting serum cytokines (IL��6, IL��8 and TNF�拨�), immunoglobulins (IgA, IgM and IgG) and complements (C3 and C4) levels in children with mycoplasma pneumoniae pneumonia (MPP). Methods 60 children with MPP (observation group) and 60 healthy children (control group) were enrolled in the study. The serum levels of IL��6, IL��8 and TNF�拨� were detected by ELISA method, the serum levels of immunoglobulins (IgA, IgM and IgG) and complements (C3 and C4) were determined by rate nephelometry method.Results The serum levels of IL��6 and IL��8 in observation group were significantly higher than those of control group (P<0.05),however there was no significant difference in TNF�拨� levels between the two groups (P> 0.05). The serum levels of IgA, IgM，IgG，C3 and C4 in observation group were significantly higher than those of control group (P<0.05).Conclusion The serum levels of IL��6 and IL��8, immunoglobulins (IgA, IgM and IgG) and complements (C3 and C4) play an important role in MPP.The detection of these parameters can more accurately determine the disease condition and patients’prognosis,which is worthy to be popularized.

【Key words】 mycoplasma pneumoniae pneumonia;IL��6; IL��8; TNF;immunoglobulin; complement

肺炎支原體肺炎(MPP)又可稱原發(fā)性非典型性肺炎，其病原體為肺炎支原體(MP)。MP廣泛分布于自然界，是一種介于細(xì)菌和病毒之間的、能獨(dú)立生活的最小微生物，是小兒呼吸道感染中較常見(jiàn)的病原體，是引起小兒下呼吸道感染的重要病原之一。已有研究認(rèn)為，在MPP發(fā)病機(jī)制中，眾多細(xì)胞因子都直接或間接地參與了免疫反應(yīng)、炎性反應(yīng)及免疫損傷[1]。認(rèn)為內(nèi)源性炎性介質(zhì)白介素��6(IL��6)、IL��8和腫瘤壞死因子�拨�(TNF�拨�)的大量釋放，是引起繼發(fā)性肺損傷的重要因素之一[2]。在MPP體液免疫方面，免疫球蛋白IgA、IgM、IgG、C3、C4與疾病的嚴(yán)重程度和病程長(zhǎng)短也是目前人們研究的焦點(diǎn)。因此本文對(duì)MPP患兒血清炎性細(xì)胞因子IL��6、IL��12、TNF�拨梁兔庖咔虻鞍譏gA、IgM、IgG、C3、C4水平進(jìn)行研究，以探討其在診治小兒MPP中的價(jià)值，并提供理論依據(jù)醫(yī).學(xué)全.在.線網(wǎng)站m.payment-defi.com。

1 資料與方法

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