| 化學(xué)名 | Pyrrolidine,1-[[2-(1,3-benzodioxol-5-yl)-1,2,4a,5,6,7,8,8a-octahydro-1-naphthalenyl]carbonyl]-,(1α,2β,4aα,8aα)-(±)
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| 藥物名稱 | Cyclostachine A
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| 異名（中) | |
| 異名（英) | |
| 分子量 | 353.44
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| 理化性質(zhì) | 無色立方結(jié)晶,熔點(diǎn)136～138°(乙醚-己烷)。UV λEtOHmax nm(logε):235(3.65),87(3.62);IR λKBrmax cm\-1:1640,1500,1480,1430,1380,1245,1190,1115,1100,1035,970,925,900,880,870,832,812,800,758,750,730,720;MSm/e (%):353(M+,100),270(45),255(44),254(90),240(18),218(45),212(8),11(15),204(8),181(6),169(6),153(10),152(10),148(12),141(14),135(78),128(20),115(25),103(12),98(95),91(24),77(22),70(24),56(35),55(92);NMR(CDCl3)δ:6.7(m,H2,5,6),3.68(d,q,J7,16=10.0,H7),5.5(br.d,J8,910,H8),5.9(d,d,d,J9,8=10,J9,10=5,J9,7=2.5,H9),3.15(d,t,J10,11a=10,J10,11e=6,J10,9=6,H10),13CNMR(CDCl3)δ:173.6(C-17),147.7和146.3(C-3,4),138.7(C-1),133.4,128.5和121.0(C-6,8,9),108.4和108.1(C-2,5),101.0(C-22),47.2和46.8(C-7,16),46.4和45.4(C-18,21),36.6和35.6(C-10,15),30.6,28.8,26.8,26.0,24.3和22.1(C-11,12,13,14,19,20)。
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| 構(gòu)效關(guān)系 | |
| 藥化作用 | 具有鎮(zhèn)靜、抗驚厥、抗菌及抗真菌作用。
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| 毒性 | |
| 臨床 | |
| 不良反應(yīng) | |
| 成分分類 | |
| 用途分類 | |
| 來源 | 胡椒科植物毛穗胡椒 Piper trichostachyon C.DC.莖。
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| 化學(xué)號(hào) | |
| 參考文獻(xiàn) | 1.《植物藥有效成分手冊(cè)》人民衛(wèi)生出版社1986
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| 分子式 | C22H27NO3
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| 熔點(diǎn) | |
| 旋光度 | |
| 沸點(diǎn) | |
| 來源拉丁學(xué)名 |
