| 化學(xué)名 | 2(3H)-Furanone,3-[2-[2,2-dimethyl-6-methylene-3-[2-(tetrahydro-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,2'-[2H]pyran]-5'-yl)ethyl]cyclohexyl]ethylidene]dihydro-4-hydroxy-,[1R-[1α,3β[5'S*[1R*(3E,4S*),3S*]]4β]]-
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| 藥物名稱 | Saponaceolide A
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| 異名（中) | |
| 異名（英) | |
| 分子量 | 518.69
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| 理化性質(zhì) | 無色針晶(丙酮-己烷),mp145～146℃,[α]20/D+78.14°(c=1.1,氯仿)。IR γmax(KBr)cm\-1:3425,2965,2930,2885,1739,1718,1670,1650,1465,1445,1430,1380,1365,1355,1318,1275,1255,1230,1205,1188,1158,1140,1115,1104,1070,1045,1018,990,980,955,930,905,884,870,847,790,750,718,704,675。LREIMS m/z(rel.int.):500(M-H20,3),482(6),464(4),442(13),175(10),161(10),149(13),147(11),143(20),142(68),141(100),140(31),137(15),135(19),133(16),131(10),125(19),123(43),121(26),119(17),109(23),107(25),105(20),99(17),97(30),95(44),93(26),91(19),83(19),81(43),79(23),71(15),69(49),67(24),57(10),55(48),43(89)。1HNMR。13CNMR。
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| 構(gòu)效關(guān)系 | |
| 藥化作用 | 細(xì)胞毒活性。對人型結(jié)腸腺癌細(xì)胞呈細(xì)胞毒作用,ID50為450±112ng/mL。
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| 毒性 | |
| 臨床 | |
| 不良反應(yīng) | |
| 成分分類 | 三萜 triterpenoid
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| 用途分類 | |
| 來源 | 口蘑科(Tricholomataceae)
皂膩口蘑 Tricholoma saponaceum (Fr.)Kummer 子實(shí)體(收率:0.058%)
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| 化學(xué)號 | 118584-14-8
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| 參考文獻(xiàn) | 《植物活性成分辭典》
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| 分子式 | C30H46O7
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| 熔點(diǎn) | |
| 旋光度 | |
| 沸點(diǎn) | |
| 來源拉丁學(xué)名 |
