| 化學(xué)名 | Morphinan-6-ol,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-,(5α,6α)-
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| 藥物名稱 | Codeine
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| 異名（中) | |
| 異名（英) | Methylmorphine,Codicept,Morphine monomethyl ether,Morphine3-methyl ether
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| 分子量 | 299.36
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| 理化性質(zhì) | 一水合物,為斜方半面棒條狀結(jié)晶或平片狀結(jié)晶(水或稀乙醇)。熔點(diǎn)154～156°(80°干燥后),d20/41.32。[α]15/D-136°(c=2,乙醇);[α]15/D-112°(c=2,氯仿)。IR λmax cm\-1:3400,3010,2930,2800,1650,1610,1510,1460,1390,1320,1280,1250,1110,1050,980,930,820,800,760,720,680;UV λH2Omax nm(ε):28(1585);MSm/e (%):299(100),229(26),300(21),298(13),214(12),282(10),242(9),230(8);NMR(CHCl3):3.40(1,2-H),6.16(3-Ome),5.15(5β-H,J6β-6.4),5.84(β,6-H),4.29(7-H,J-9.6),4.74(8-H,J-9.6),6.63(9α-H,J14-3.2,J10α-5.6),6.92(10β-H,J10α-18.4),7.56(N-Me),13CNMR(CDCl3)δ:119.3(c-1),112.8(c-2),142.0(c-3),146.2(c-4),91.3(c-5),66.4(c-6),133.2(c-7),128.1(c-8),58.7(c-9),20.4(c-10),127.0(c-11),130.9(c-12),43.0(c-13),40.7(c-14),35.8(c-15),46.4(c-16),43.0(Nme),56.2(3-Ome)。
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| 構(gòu)效關(guān)系 | |
| 藥化作用 | |
| 毒性 | |
| 臨床 | |
| 不良反應(yīng) | |
| 成分分類 | |
| 用途分類 | |
| 來(lái)源 | |
| 化學(xué)號(hào) | |
| 參考文獻(xiàn) | 1.《植物藥有效成分手冊(cè)》人民衛(wèi)生出版社1986
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| 分子式 | C18H21NO3
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| 熔點(diǎn) | |
| 旋光度 | |
| 沸點(diǎn) | |
| 來(lái)源拉丁學(xué)名 |
